No, and here is why:
I think the quality of Skype sucks.
People often times confuse Skype with the advantages of running a VoIP solution. Skype is closed source software, you don't have the ability to make changes to anything. Reverse engineering the protocol will violate your EULA. Despite the fact that Skype doesn't give you the freedom to look at what you're using, they do make ample use of other OpenSource code. This is pretty poor form.
Also, the protocol that Skype uses is not an open standardized protocol. Not much testing has been done outside of Skype on the reliability or efficiency of this protocol.
Skype steals your bandwidth if you aren't running a NAT, and if you are, you're at the mercy of someone else. From the perspective of security, if you are behind a NAT all of your calls are going through some other users computer. If a weakness was discovered (and infact many have) in the skype protocol, a potential user could listen to your phone calls. This would likely be embarrassing when your phone call gets posted to this message forum...
You're also going to be on some funky crap in terms of what you connect to the PSTN with. An old analog phone is really killer, you can choose your own longdistance provider, etc. With Skype you're at the mercy of whomever, and who knows what type of cruft is going to be out on outdial (weird ANI II digits for example)
Skype is all crazy peer to peer. Great...sounds real reliable.
I dunno. Why not pick something that's open, so you can get in and play with it? Its like Skype has all of the disadvantages of VoIP and none of the advantages. You get crappy bandwidth-dependant quality, non-POTS termination, no choice of LD carrier. Yet you don't have the ability to choose what codecs you're running, or setup kickass asterisk shit.
