Still tons of unnecessary commas.
You have two options. In one option, only the first and last comma are used. Since the rest of the sentence is completely free of lists and independent clauses, it could all be used as one sentence. Otherwise, you should divide up some of these lists into sentences. This would actually be preferred, since you start with a "first" but you never use a "second" or "following that" or any other prepositional phrase other than "then"; that, however, is pretty weak.
Secondly, you want to use city's filth, not cities filth. You want the imply ownership, not a plural noun.
Nicotine-stained should be hyphenated, though that could also be a matter of personal opinion.
No matter what, some of these commas should not be used. IE: "...until they are flushed out to sea with the rest of the city's filth..." is a clause by itself and should not, under any circumstances, have a comma dividing it. There's no reason to.
I know you want to create a run-on sentence, but this style of writing hasn't been popular since the turn of the 20th century, and, as such, I would not advise using it if you are unsure of how to properly divide independent and dependent clauses.
