Nah, their last hit single was Ch-Ch-Check It Out off the 2005 disc 'To The 5 Boroughs'.
Was it a hit, though? I don't think I've heard of it.
Yeah, I think it was at least in the Billboard top 25, I couldn't go very far that year without hearing that track.
edit: Looks like it made #68 on the Top 100, but was number 1 on the modern rock charts.
Their last album, The Mix-Up was a completely instrumental tracks, and I thought it was completely decent. Apparently they're releasing two more albums in '11, which is supposed to be a radical change in their sound. Kind of interested in hearing which shitty direction they go in.
The reason The Beasties have been out of the spotlight for so long was Yauch had cancer.